Human Sera
Cayman Chemical TRAP6 amIDtrIfluoROCTAt 100mg
A peptide PAR1 agonist; induces platelet aggregation in vitro (EC50 = 0.15 µM); induces relaxation of isolated guinea pig internal anal sphincter strips at 30 µM; increases cigarette smoke extract-induced IL-8 release from isolated human bronchial epithelial cells at 50 µM
Cayman Chemical A2764hydrochlorIde 50mg
An inhibitor of K2P18.1/TRESK (IC50 = 11.8 µM in ionomycin-stimulated Xenopus oocytes expressing the mouse receptor); selective for K2P18.1/TRESK over K2P2.1/TREK1, K2P10.1/TREK2, K2P4.1/TRAAK, K2P3.1/TASK1, K2P3.2/TASK2, K2P3.3/TASK3, K2P16.1/TALK1, and K2P13.1/THIK1 at 100 µM; inhibits basal potassium currents in isolated mouse dorsal root ganglion neurons at 100 µM
Cayman Chemical AzImIlIdehydrochlorIde 50mg
A class III antiarrhythmic agent; blocks IKr and IKs currents in isolated guinea pig ventricular myocytes (IC50s = 0.3 and 3 μM, respectively); prolongs APD in isolated calf Purkinje fibers and ventricular trabeculae from 0.1-10 μM; increases the ERP in isolated perfused guinea pig hearts and ferret papillary muscles; increases ERP and the absolute refractory period and decreases heart rate in dogs from 0.3-30 mg/kg; reduces mean arrhythmia score in a rat model of coronary artery ligation and reperfusion-induced severe ventricular arrhythmia; prevents sustained and non-sustained ventricular tachyarrhythmias in dogs from 10-30 mg/kg
Cayman Chemical TrIazavIrIn 100mg
An antiviral agent; inhibits lung viral accumulation in a mouse model of H5N1 influenza A infection at 1 mg/kg; inhibits platelet aggregation in a rat model of LPS-induced hypercytokinemia at 20 mg/kg
Cayman Chemical AzatdInmaleate 50mg
An antihistamine with anticholinergic and antiserotonergic activities; histamine H1 receptor antagonist (Ki = 3.9 nM); inhibits histamine- and acetylcholine-induced contractions in isolated guinea pig ilium and 5-HT-induced contractions in isolated rat uterus (EC50s = 6.5, 10, and 14 nM, respectively); delays the onset of dyspnea induced by aerosolized histamine, 5-HT, or acetylcholine in guinea pigs; prevents histamine-induced lethality in guinea pigs and paw edema in mice (ED50s = 9 and 68 μg/kg, respectively); increases survival in guinea pig and mouse models of anaphylactic shock (PD50s = 0.024 and 0.019 mg/kg, respectively)
Cayman Chemical TAS 103hydrochlorIde 50mg
A DNA topoisomerase I and II inhibitor (IC50s = 2 and 6.5 µM, respectively); stabilizes topoisomerase I-DNA and topoisomerase II-DNA cleavable complexes in KB cells at 3 µM; cytotoxic to P388 and KB cells (IC50s = 1.1 and 9.6 nM, respectively); reduces pulmonary metastasis in murine B16-BL6 melanoma and UV-2237M fibrosarcoma models of lung metastasis at 15, 26, and 45 mg/kg per day; reduces tumor growth in a variety of human cancer mouse xenograft models
Cayman Chemical PhIlygenIn 100mg
A lignan with diverse biological activities; scavenges peroxide and DPPH radicals in cell-free assays (IC50s = 10.5 and 19.1 µM, respectively); inhibits LPS-induced production of IL-1β, IL-6, TNF-α, and the fibrosis markers collagen I and α-SMA in LX-2 hepatic stellate cells from 25-200 UG/ml; reduces serum levels of ALT, AST, SOD, and MDA and prevents hepatic necrosis in a mouse model of carbon tetrachloride-induced liver injury
MOLECULAR DEPOT LLC RF Serum 7500-9999 - 1 mL
High Rheumatoid Factor Positive Serum is human serum containing high levels (7500-9999 IU/mL) of Rheumatoid Factor antibodies (RF) Titer has been measured with the RF Latex method No preservatives have been added All units have tested negative for infectious agents at the single donor level Available as single donor units or as pooled units For in vitro research use only
Cayman Chemical PIcrosIde II 50mg
A flavonoid with diverse biological activities; decreases expression of FATP5 and SCD and inhibits free fatty acid-induced lipid accumulation in HepG2 cells at 10 µM; inhibits RANKL-induced osteoclast formation in isolated murine bone marrow cells and decreases the size of bone resorption pits in bovine bone slices; inhibits LPS-induced trabecular bone loss in a mouse model of inflammatory osteoporosis at 10 and 60 mg/kg; prevents ischemia-reperfusion-induced testicular apoptosis and MDA production in a rat model of testicular torsion; reduces airway inflammation, lung mucus hypersecretion, and BALF inflammatory cell infiltration in a mouse model of house dust mite-induced allergic asthma
Cayman Chemical D-LysIn lactam 50mg
A chiral building block; has been used in the synthesis of a chiral synthetic antibiotic intermediate, as well as in the stereoselective synthesis of NK receptor antagonists
Cayman Chemical Benzyl2ACTAmIdo2deoxya 50mg
An inhibitor of mucin synthesis; inhibits glucosamine labeling in Caco-2, HT-29, and T84 colon cancer cells at 2 mM; enhances 5-fluorouracil-induced cell death in Capan-1 and HPAF-II cells at 0.4, 0.6, and 0.8 mg/ml; LS 174T colon cancer cells grown in the presence of benzyl-α-GalNAc exhibit reduced liver metastasis in a mouse xenograft model compared with control LS 174T cells